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Progress in Inflammation Research: Lymphocyte Trafficking in Health and Disease

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Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e. g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.

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Progress in Inflammation Research: Lymphocyte Trafficking in Health and Disease, Raffaele Badolato, Silvano Sozzani, Michael J. Parnham

Jazyk
Rok vydania
2006
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Titul
Progress in Inflammation Research: Lymphocyte Trafficking in Health and Disease
Jazyk
anglicky
Vydavateľ
Birkhäuser
Rok vydania
2006
Väzba
pevná
Počet strán
242
ISBN10
3764373083
ISBN13
9783764373085
Série
Anotácia
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e. g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.