Piet Herdewijn Knihy

Dedicated to the fond memory of two great pioneers of this science, Leslie E. Orgel and Stanley L. Miller, this compilation of reviews and original manuscripts provides an overview of the current state of the art, written by some of the eminent „players“ in this creative domain of „explorative chemistry“. Since we are still far from finding a definitive answer to the most fundamental of questions in science, „chemistry“ here is defined in its broadest sense. It is against this background that the contributions cover such a wide range of theories, including chemistry and selection, evolution of the pioneer organism, chemical aspects of synthetic biology, ribozyme catalysis of metabolism in the RNA world, intractable mixtures and the origin of life, the chemical etiology of nucleic acids, interstellar amino acids, and even the chemistry that preceded life's origin. The majority of the articles reproduced in this volume originally appeared in a special issue of Chemistry & Biodiversity under the title "On Chemistry Leading to Life's Origin".

Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances.The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs.Essential reading for every scientist working in this area.