Satya Prakash Gupta Knihy

Satya P. Gupta's Hydroxamics Acids is the first book to compile invited articles written by international experts on the class of compounds hydroxamic acids. Found to possess a wide spectrum of biological activities, the hydroxamic acids are of interest to theoretical and experimental chemists who can study and make use of them in drug design and development. Chapters in this book provide a diverse and comprehensive coverage of this compound class and consequently this publication is a valuable resource for researchers in chemical, pharmaceutical and biological sciences.

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.

Inhaltsverzeichnis P. R. Duchowicz, E. A. Castro, A. A. Toropov, E. Benfenati: Applications of Flexible Molecular Descriptors in the QSPR-QSAR Study of Heterocyclic Drugs.- S. C. Basak, D. Mills, B. D. Gute, R. Natarajan: Predicting Pharmacological and Toxicological Activity of Heterocyclic Compounds Using QSAR and Molecular Modeling.- M. N. Ponnuswamy, M. M. Gromiha, S. M. Malathy Sony, K. Saraboji: Conformational Aspects and Interaction Studies of Heterocyclic Drugs.- S. Khanna, R. Bahal, P. V. Bharatam: In silico Studies on PPARg Agonistic Heterocyclic Systems.- R. Garg, B. Bhhatarai: QSAR and Molecular Modeling Studies of HIV Protease Inhibitors.

Die quantitative Struktur-Aktivitäts-Beziehung (QSAR) ist ein wichtiger Ansatz für die Entwicklung von Arzneimitteln, um die Beziehung zwischen der chemischen Struktur und ihrer biologischen Aktivität zu verstehen. Das Buch beschreibt eine kurze Einführung in das Hepatitis-C-Virus (HCV), den Lebenszyklus, die identifizierten Targets und die aktuellen Fortschritte bei der Entwicklung von Anti-HCV-Wirkstoffen. 2D- und 3D-QSAR-Studien für Anti-HCV-Verbindungen aus verschiedenen Kategorien, die auf die NS5B-Polymerase abzielen, wurden einbezogen. Einige der ausgewählten Kategorien sind Nukleoside und Nicht-Nukleoside.