Kar Neng Lai Knihy

Diabetic nephropathy has emerged as a leading cause of end-stage renal disease, driven by rising obesity, diabetes, and metabolic syndromes. This publication offers a concise overview of the current state of clinical and basic research in the field. It begins with an exploration of the epidemiology and genetics of diabetic nephropathy across various ethnic groups, followed by a review of its clinical manifestations, associations with metabolic syndrome and obesity, and underlying pathology. The latest findings on pathogenetic, epigenetic, and inflammatory mechanisms are also discussed. Advances in tubulopathy, the kallikrein-kinin system, animal models, and the roles of lipoproteins and proteomics are examined. Therapeutic approaches such as experimental anti-fibrotic strategies, stem cell therapy, and pancreatic transplantation are highlighted, along with expert reviews on new onset diabetes post-transplantation and preventive strategies for diabetic nephropathy. Authored by leading international experts, this publication is highly recommended for nephrologists, diabetologists, internists, transplant physicians, scientists, geneticists, epidemiologists, and stem cell biologists engaged in diabetic nephropathy research.