Ajay Niranjan Knihy

Since its introduction 52 years ago, Leksell radiosurgery has become a widely applied technique for the management of a diverse group of vascular, neoplastic, and functional disorders. This publication presents an update on state-of-the-art radiosurgery technology, including outcomes, by the pioneers in the field. Experts have contributed chapters on various topics. They provide a history of the development of Leksell Gamma Knife and its evolution from frame-based to the inclusion of mask-based radiosurgery in the latest Gamma Knife model. For beginners, there is valuable information related to imaging, quality assurance, patient care, anesthesia, and regulatory requirements. Advance users will appreciate the summary of the long-term outcome of important indications. Additional chapters on cavernous malformation, orbital, uveal, and ocular disorders clarify the role of radiosurgery. This book is a concise overview for physicians interested in radiosurgery. It will be of great value to neurosurgeons, radiation oncologists, and medical physicists concerned with learning about the indications of radiosurgery.

This book summarizes the current state of movement disorder management and the role of surgical therapies as an alternative to medication. Following a chapter on the history of movement disorder surgery, leaders in their fields describe the pathophysiology, functional neuroanatomy, clinical presentation, and medical management of Parkinson’s disease, dystonia, and essential tremor. This is followed by chapters on the spectrum of movement disorder surgery itself, from the lesioning procedures of radiofrequency ablation, stereotactic radiosurgery, and high-frequency ultrasound to the modulatory procedures of “asleep”, image-guided deep brain stimulation (DBS) and “awake”, microelectrode-guided DBS. The final chapters focus on closed-loop DBS, drug-delivery, gene therapy, and other emerging neurosurgical therapies, highlighting long-standing experimental strategies that are reaching exciting phases of clinical translation. This volume is a valuable tool for accessing the wide spectrum of concepts that currently define this dynamic field.

The increasing recognition of concussion and its associated consequences has focused international attention on mild traumatic brain injury. The need for early diagnosis, evaluation, and management has expanded dramatically. This volume includes the experience of leading experts who describe the recent advances in the pathophysiology, biomechanics, imaging definition, and management of concussion. Advanced imaging and electrophysiological techniques are being used to help delineate the underlying metabolic and ultrastructural effects of concussive injuries. Papers in this volume review the role of emerging techniques including fMRI, SPECT, PET, DTI, MRS, and MEG, as well as report on multimodality concussion management programs which offer guidelines for selecting relevant team members, assessing community needs, and implementing management strategies that align with current practice standards. This publication provides neurosurgeons, neurologists, trauma and sports medicine specialists, physiatrists, neuropsychologists, and neuroscientists with a comprehensive overview of the current understanding of the causes of mild traumatic brain injury or concussion, newer methods to evaluate it, and current and evolving multimodality management strategies.

An excellent summary of more than 30 years of accumulated experience Clinical outcomes of brain vascular malformation have been greatly improved by advances in microsurgery, endovascular techniques and stereotactic radiosurgery. Radiosurgery has proven to be the least invasive technique and is associated with documented long-term success. The papers in this volume present the experience of leading brain vascular malformation specialists who describe the outcome of radiosurgery for arteriovenous malformations, cavernous malformations and dural arteriovenous fistulas. These reviews expand the knowledge of the role of stereotactic radiosurgery alone or in combination with other treatment modalities. Evidence-based guidelines are included in each section to provide a summary of the current management strategies. This unique publication includes additional data that will further define the long-term benefit and risks of radiosurgery for these often complex vascular disorders and makes valuable reading for neurosurgeons, neurologists and endovascular specialists interested in an excellent summary of more than 30 years of accumulated experience in the management of brain vascular malformations.