H. Jahn Knihy

This book documents an international symposium focused on small proteins in relation to renal physiology, metabolic functions, kidney damage detection, and drug-induced nephrotoxicity. It presents both basic and clinical findings. The first section discusses the catabolism of low molecular weight proteins, including hormonal (insulin, glucagon, growth hormone) and nonhormonal (interferons, ß2-microglobulin, aprotinin) proteins. Notably, proximal tubular cells are identified as a key transport system for removing proteins, polypeptides, and small peptides. The second section addresses specific urinary markers for renal damage, providing clinicians with reliable tools for monitoring nephrotoxicity through metabolic and structural enzyme changes. The third section explores the role of drugs in nephrotoxicity, featuring comprehensive data on piperacillin and aminoglycoside antibiotics, along with dosage guidelines to prevent tubular damage. The concluding papers discuss the link between non-steroidal anti-inflammatory drugs and increased nephrotoxicity risk. With state-of-the-art reviews and original data, this book is vital for enzymologists, pharmacologists, drug researchers, and clinical and research nephrologists.