Robert Gurny Knihy

There is a growing interest in mimicking the temporal modulation of therapeutic agents such as endogenous hormones. An accurate control of drug input has proved to be a valuable new concept in modern clinical pharmacology. Important examples include the pulsatile administration of gonadotropin releasing hormone (GNRH) for the induction of fertility of corticostroids in the treatment of adrenal insufficiency, and insulin pumps which mimic fasting alternating with meal stimulated insulin secretion. Persons interested: This highly topical book is intended for all those who are involved in the development of drug administration with pulsatile or temporal control of drug delivery. Regulatory authorities, members of universities and education departments as well as scientists from industry will be confronted with such new concepts. This book, written by experts of international repute, should be present in all libraries dealing with new pharmaceutical concepts.

Dermal and Transdermal delivery of drugs has become over this decade one of the most exciting areas of pharmaceutical research. The various topics addressed in this book highlight the following: - physiochemical, biological and biochemical aspects of the skin - barrier function of the skin - metabbolisme of the skin - penetration anhancement - development and evaluation of new preparations including transdermal patches - local and systemic effects - pharmacokinetic investigations - clinical trials - regulatory aspects This book primarily intended for all scientists involved in the development of dermal and transdermal preparations and is especially recommended to those interested in the recent advances in the design of controlled delivery systems.

The First International Joint Workshop of the Association for Pharmaceutical Technology (APV) and the Controlled Release Society (CRS) took place in Leiden from May 22-24, 1989. Bioadhesion presents significant challenges and opportunities for the development of controlled drug delivery systems. The growing interest in bioadhesive systems stems from their ability to enhance drug bioavailability through localization in specific regions, prolong residence time, and optimize contact with absorbing surfaces. These features allow for reduced daily dosages across various applications, including the eye, mouth, gastrointestinal tract, rectum, and vagina, ultimately improving patient compliance. This APV paperback encompasses all lectures from the workshop, beginning with foundational aspects of bioadhesion and the physiological roles of mucus and mucoadhesion. Subsequent chapters focus on application routes such as buccal, nasal, gastrointestinal, and ocular. The concluding sections explore future trends in bio(muco)adhesive drug delivery systems. This book serves as a valuable resource for scientists in both industry and academia involved in developing bioadhesive dosage forms and those interested in advancements in controlled drug delivery system design.