A Contribution to Design Gassing Crystallization Processes

Viac o knihe

Batch cooling crystallization is essential in chemical, biochemical, and pharmaceutical processes for tailoring solid product properties. The efficiency of solid production hinges on nucleation and subsequent crystal growth. To control nucleation, established methods like seeding and sonocrystallization are commonly used. Gassing crystallization, an innovative technique, introduces gas bubbles into the metastable zone of a batch crystallizer to influence nucleation. This work aims to advance gassing crystallization as an alternative to traditional methods. It is divided into two parts: the first investigates gassing crystallization's potential in designing product properties, quantifying its effects on nucleation kinetics, and comparing it to seeding and standard cooling crystallization. The second part transitions gassing crystallization from lab to pilot scale, developing and validating a transfer strategy with a different substance system. The findings indicate that gassing crystallization is a viable nucleation technology at both lab and larger scales, demonstrating competitive potential against established methods. Notably, gassing significantly impacts the metastable zone width and nucleation mechanisms, providing a foundation for its application in various crystallization phenomena. Its ease of integration into batch crystallization setups suggests it should be considered for future nucleation-affecting technologies.