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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.
Nákup knihy
Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Jazyk
- Rok vydania
- 2014
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Nikto zatiaľ neohodnotil.
- Podtitul
- Synthesis and Biological Evaluation
- Jazyk
- anglicky
- Autori
- Colm Duffy
- Vydavateľ
- Springer, Berlin
- Rok vydania
- 2014
- Väzba
- mäkká
- Počet strán
- 152
- ISBN13
- 9783642438929
- Série
- Springer Theses
- Štítky
- Náučná literatúra
- Anotácia
- Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.